DOD Amyotrophic Lateral Sclerosis, Therapeutic Development Award
The summary for the DOD Amyotrophic Lateral Sclerosis, Therapeutic Development Award grant is detailed below.
This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants.
Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact.
If any section is incomplete, please visit the website for the Dept of the Army USAMRAA, which is the U.S. government agency offering this grant.
DOD Amyotrophic Lateral Sclerosis, Therapeutic Development Award: The FY24 ALSRP Therapeutic Development Award supports research ranging from preclinical validation of therapeutic leads through Food and Drug Administration (FDA) Investigational New Drug (IND)-enabling studies. The proposed studies are expected to be empirical in nature and product-driven. Applicants with limited ALS experience are strongly encouraged to include collaborators with substantial experience in the relevant ALS model systems, endpoints, and pathophysiology.Applications supported by this award must begin with lead compounds in hand and must include proof-of-concept efficacy data in at least one preclinical model system of ALS, including whole animal and cellular model systems.Examples of activities that will be supported by this award include:Confirmation of candidate therapeutics obtained from screening or by other means, including optimization of potency and pharmacological properties and testing of derivatives and sister compounds.Validation of pilot efficacy studies (such as from an ALSRP Therapeutic Idea Award [TIA]), including the use of additional ALS model systems and/or replicating preliminary data with more time points or additional doses.ND-enabling studies to include: compound characterization; absorption, distribution, metabolism, and excretion (ADME) studies; studies on formulation and stability leading to Good Manufacturing Practice production methods; dose/response and toxicology studies in relevant model systems.Applicants seeking support for basic research focused on ALS drug discovery are encouraged to apply for the FY24 ALSRP TIA (Funding Opportunity Number HT942524 ALSRP TIA), which does not require preliminary data (https://cdmrp.health.mil/funding/alsrp).Mechanism-specific, predictive/cohort-selective, target engagement, and pharmacodynamic biomarker development, in parallel to the main therapeutic effort, is a critical component of the FY24 ALSRP Therapeutic Development Award. If biomarkers are already available or currently in development, how the existing biomarkers will improve trial design, patient selection, and efficiency or interpretation of the proposed ALS therapeutic approach must be apparent in the application. Development of biomarkers for the purposes of diagnosis, prognosis, or measurement of general disease progression without consideration of the therapeutic development process will not be supported. Applicants seeking support for biomarker development independent of therapeutic development are encouraged to apply for the FY24 ALSRP Clinical Outcomes and Biomarkers Award (Funding Opportunity Number HT942524ALSRPCOBA).
Federal Grant Title: | DOD Amyotrophic Lateral Sclerosis, Therapeutic Development Award |
Federal Agency Name: | Dept of the Army USAMRAA (DOD-AMRAA) |
Grant Categories: | Science and Technology and other Research and Development |
Type of Opportunity: | Discretionary |
Funding Opportunity Number: | HT942524ALSRPTDA |
Type of Funding: | Cooperative Agreement |
CFDA Numbers: | 12.420 |
CFDA Descriptions: | Information not provided |
Current Application Deadline: | July 10th, 2024 |
Original Application Deadline: | July 10th, 2024 |
Posted Date: | March 25th, 2024 |
Creation Date: | March 25th, 2024 |
Archive Date: | August 9th, 2024 |
Total Program Funding: | $9,600,000 |
Maximum Federal Grant Award: | |
Minimum Federal Grant Award: | |
Expected Number of Awards: | 4 |
Cost Sharing or Matching: | No |
Last Updated: | March 25th, 2024 |
- Applicants Eligible for this Grant
- Unrestricted (i.e., open to any type of entity below), subject to any clarification in text field entitled "Additional Information on Eligibility"
- Grant Announcement Contact
- CDMRP Help Desk
Phone: 301-682-5507
Email: [email protected]
CDMRP Help Desk - Similar Government Grants
- • DoD Prostate Cancer, Idea Development Award
- • DoD Prostate Cancer, Exploration - Hypothesis Development Award
- • DoD Prostate Cancer, Early Investigator Research Award
- • DoD Prostate Cancer, Physician Research Award
- • DoD Peer Reviewed Cancer, Idea Award
- • FY2006 Deployed War Fighter Protection Research Program
- • Department of Defense (DOD) Fiscal Year 2003 (FY03) Breast Cancer Research Program (BCRP)C...
- • Department of Defense (DOD) Fiscal Year 2004 (FY04) Breast Cancer Research Program (BCRP) ...
- More Grants from the Dept of the Army USAMRAA
- • DoD Prostate Cancer, Idea Development Award
- • DoD Prostate Cancer, Exploration - Hypothesis Development Award
- • DoD Prostate Cancer, Early Investigator Research Award