Next Generation Genetic Association Studies (U01)

The summary for the Next Generation Genetic Association Studies (U01) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.
Next Generation Genetic Association Studies (U01): Purpose. This FOA issued by the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, encourages applications from institutions or organizations that propose to utilize cellular reprogramming, molecular profiling, and genomics to investigate functional aspects of genetic variation in humans. NHLBI is soliciting a phased technology development and implementation program whose goal is to add a functional dimension to genomic studies by combining cellular reprogramming strategies with molecular profiling or cellular assays, followed by integration of this information with existing genotypic and clinical phenotypic data to assess how naturally occurring human genetic variation influences the activities of biological networks in cell-based models of disease. Since the design and conduct of such studies will require several areas of expertise, applicants are encouraged to include multiple PIs on the application. Mechanism of Support. This FOA will utilize the U01 (cooperative agreement) grant mechanism. Applicants will submit a single application organized into three phases, beginning with Phase I which will have technology development to generate induced pluripotent stem (iPS) cells from human samples and differentiate these iPS cells into tissues relevant to heart, lung, blood and sleep (HLBS) diseases. Phase II involves ramping up the technology developed in Phase I for high throughput generation of differentiated cells from iPS cells in population samples. Phase III will utilize technology developed in Phases I and II to test genome wide association study (GWAS) generated functional hypotheses in cell-based models of disease. Applicants may propose Phases I to III or II to III depending on the current state of iPS generation and cell type differentiation technology needed to meet their specific aims. Inclusion of Phase I is dependent on the validation and reproducibility of cell differentiation protocols for the specific cell type(s) proposed in the application.
Federal Grant Title: Next Generation Genetic Association Studies (U01)
Federal Agency Name: National Institutes of Health
Grant Categories: Education Health
Type of Opportunity: Discretionary
Funding Opportunity Number: RFA-HL-11-006
Type of Funding: Cooperative Agreement
CFDA Numbers: 93.837
CFDA Descriptions: Cardiovascular Diseases Research
Current Application Deadline: Jun 15, 2010
Original Application Deadline: Jun 15, 2010
Posted Date: Mar 15, 2010
Creation Date: Mar 15, 2010
Archive Date: Jul 16, 2010
Total Program Funding: $76,000,000
Maximum Federal Grant Award:
Minimum Federal Grant Award:
Expected Number of Awards:
Cost Sharing or Matching: No
Applicants Eligible for this Grant
State governments - County governments - City or township governments - Special district governments - Independent school districts - Public and State controlled institutions of higher education - Native American tribal governments (Federally recognized) - Public housing authorities/Indian housing authorities - Native American tribal organizations (other than Federally recognized tribal governments) - Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education - Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education - Private institutions of higher education - For profit organizations other than small businesses - Small businesses - Others (see text field entitled "Additional Information on Eligibility" for clarification)
Additional Information on Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Link to Full Grant Announcement
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