Optimization of Small Molecule Probes for the Nervous System (R21)
The summary for the Optimization of Small Molecule Probes for the Nervous System (R21) grant is detailed below.
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Optimization of Small Molecule Probes for the Nervous System (R21): Purpose. The aim of this FOA issued by the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), and the National Institute on Drug Abuse (NIDA) is to facilitate the discovery of new small molecule probes for investigating biological function in the nervous system by providing funding for advanced medicinal chemistry and the biological testing of compounds. Eligible Investigators will have identified probe candidates via screening of small molecule collections, using in vitro assays of biological activity developed to interrogate these collections, and be able to show that the structural features of these small molecules are related to their biological activity. Project proposals should nominate small molecule probe candidates from distinct structural series for the further, iterative design and testing of analogues in structure-activity relationship studies, using in vitro assays of biological function adapted to the medium throughput screening requirements of this work. These studies should have the goal of developing a small molecule probe possessing the attributes (eg: affinity, selectivity, activity) required for its use in future pharmacological studies proposed by the investigator. Applicants are strongly encouraged to utilize publicly available cheminformatic capabilities for the acquisition of compounds, and semi-custom synthesis of analogues, which is required of these studies.
Federal Grant Title: | Optimization of Small Molecule Probes for the Nervous System (R21) |
Federal Agency Name: | National Institutes of Health |
Grant Categories: | Health |
Type of Opportunity: | Discretionary |
Funding Opportunity Number: | RFA-NS-09-003 |
Type of Funding: | Grant |
CFDA Numbers: | 93.273 |
CFDA Descriptions: | Alcohol Research Programs |
Current Application Deadline: | Mar 03, 2009 |
Original Application Deadline: | Mar 03, 2009 |
Posted Date: | Dec 30, 2008 |
Creation Date: | Dec 31, 2008 |
Archive Date: | Apr 02, 2009 |
Total Program Funding: | |
Maximum Federal Grant Award: | $0 |
Minimum Federal Grant Award: | |
Expected Number of Awards: | |
Cost Sharing or Matching: | No |
- Applicants Eligible for this Grant
- State governments - County governments - City or township governments - Special district governments - Independent school districts - Public and State controlled institutions of higher education - Native American tribal governments (Federally recognized) - Public housing authorities/Indian housing authorities - Native American tribal organizations (other than Federally recognized tribal governments) - Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education - Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education - Private institutions of higher education - For profit organizations other than small businesses - Small businesses
- Link to Full Grant Announcement
- Information not provided
- Grant Announcement Contact
- NIH OER Webmaster [email protected] If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster [email protected] [[email protected]]
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