Osteoimmunology- Crosstalk between Immune System and Bone (R21)

The summary for the Osteoimmunology- Crosstalk between Immune System and Bone (R21) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.

Osteoimmunology- Crosstalk between Immune System and Bone (R21): The Exploratory/Developmental Grant (R21) mechanism is intended to encourage exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research. Purpose. The goal of this FOA is to solicit novel research projects designed to provide a fundamental understanding of the intersystem crosstalk between alveolar bone and the immune system, and how osteoimmunology operates in normal and pathologic conditions. It will contribute to our understanding of how both systems are regulated in a physiologic context, at the molecular and cellular levels and at the level of organ systems. Specifically this initiative will solicit research that will identify the influence of the immune system on oral bone biology; the extent to which normal immune responses affect oral bone homeostasis; the consequences of oral bone metabolism on adaptive immune responses; the interplay between the immune system and age-related oral bone changes; and the changes in the host immune system that impact oral bone loss. The emerging field of osteoimmunology is important for formulating intervention strategies for periodontitis as well as for basic and clinical studies in related fields. Mechanism of Support. This Funding Opportunity Announcement (FOA) will utilize the This FOA will utilize the NIH Research Project Grant (R21) award mechanism and runs in parallel with an FOA of identical scientific scope, RFA-DE-08-006, that solicits applications under the R01 award mechanism Funds Available and Anticipated Number of Awards. NIDCR intends to commit up to a total of $1.0 million in FY2008 to support meritorious projects that are responsive to this FOA. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Budget and Project Period. R21: The total project period for an application submitted in response to this funding opportunity may not exceed two years. Direct costs are limited to $275,000 over an R21 two-year period, with no more than $200,000 in direct costs allowed in any single year. Eligible Institutions/Organizations. Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Small Business; For-Profit Organization (Other than Small Business); State Government; U.S. Territory or Possession; Indian/Native American Tribal Government (Federally Recognized); Indian/Native American Tribal Government (Other than Federally Recognized); Indian/Native American Tribally Designated Organization; Non-domestic (non-U.S.) Entity (Foreign Organization); Hispanic-serving Institution; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Regional Organization; Eligible Project Directors/Principal Investigators (PDs/PIs): Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. Number of Applications. Applicants may submit more than one application, provided each application is scientifically distinct. Renewals and Resubmissions.. At this time it is not known if this FOA will be reissued. Number of PDs/PIs. More than one PD/PI, or multiple PDs/PIs, may be designated on the application.