HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required)

The summary for the HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.

HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required): The NIH Helping to End Addiction Long-term® (HEAL) Initiative is releasing this Notice of Funding Opportunity (NOFO) to support a phased mechanistic clinical research program focusing on understudied biological mechanisms that drive joint pain. The phased projects supported by this program (of up to five years total in duration) will first identify and validate multi-tissue mechanisms underlying joint pain, then test non-pharmacologic or multimodal interventions that directly target these mechanisms. The initiative responds to priorities identified in the 2023 HEAL Whole Joint Pain Workshop and supports the broader goals of the NIH HEAL Initiative and the Make America Healthy Again vision by advancing safe, non-addictive, and prevention-oriented approaches to chronic pain.

Federal Grant Title:	HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required)
Federal Agency Name:	National Institutes of Health (HHS-NIH11)
Grant Categories:	Health
Type of Opportunity:	Discretionary
Funding Opportunity Number:	PAR-27-045
Type of Funding:	Grant
CFDA Numbers:	93.121, 93.213, 93.273, 93.286, 93.473, 93.846, 93.853, 93.866
CFDA Descriptions:	Information not provided
Current Application Deadline:	October 30th, 2026
Original Application Deadline:	October 30th, 2026
Posted Date:	September 28th, 2026
Creation Date:	September 28th, 2026
Archive Date:	December 29th, 2026
Total Program Funding:
Maximum Federal Grant Award:
Minimum Federal Grant Award:
Expected Number of Awards:
Cost Sharing or Matching:	No
Last Updated:	September 28th, 2026

Applicants Eligible for this Grant: State governments - County governments - City or township governments - Special district governments - Independent school districts - Public and State controlled institutions of higher education - Native American tribal governments (Federally recognized) - Public housing authorities/Indian housing authorities - Native American tribal organizations (other than Federally recognized tribal governments) - Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education - Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education - Private institutions of higher education - For-profit organizations other than small businesses - Small businesses - Others (see text field entitled "Additional Information on Eligibility" for clarification.)
Additional Information on Eligibility: Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Grant Announcement Contact: NCCIH Program Officer
[email protected]
[email protected]
Similar Government Grants: • Collaborative Program Grant for Interdisciplinary Teams (RM1 Clinical Trial Optional); • Specialized Programs of Research Excellence (SPOREs) in Human Cancers for Years 2027, 2028...; • Implementation Science to Advance HIV Prevention, Treatment, and Care (R61/R33 Clinical Tr...; • NIH Brain Development Cohorts (NBDC) and Population Assessment of Tobacco and Health ...; • Grants for Early Medical/Surgical Specialists' Transition to Aging Research (GEMSSTAR) (R0...; • Epidemiological and Behavioral Research in Oral Health; • Metagenomic Analyses of the Oral Microbiome; • Phase Iii Clinical Trials in Oral Infectious Diseases
More Grants from the National Institutes of Health: • Specialized Alcohol Research Centers (P50 Clinical trial Optional); • Limited Competition: Biospecimen Banks to support NCI National Clinical Trials Network Bio...; • Single Source for the Continuation of the Physiology of the Weight Reduced State (POWERS) ...; • Assessing the Feasibility of Incorporating Mechanisms in Multi-site Clinical Trials of Min...; • Early-Onset Cancers: Investigating Etiology, Mechanisms, and Early Detection Strategies (R...