Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (RDCRN) (U54 Clinical Trial Optional)

The summary for the Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (RDCRN) (U54 Clinical Trial Optional) grant is detailed below. This summary states who is eligible for the grant, how much grant money will be awarded, current and past deadlines, Catalog of Federal Domestic Assistance (CFDA) numbers, and a sampling of similar government grants. Verify the accuracy of the data FederalGrants.com provides by visiting the webpage noted in the Link to Full Announcement section or by contacting the appropriate person listed as the Grant Announcement Contact. If any section is incomplete, please visit the website for the National Institutes of Health, which is the U.S. government agency offering this grant.

Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (RDCRN) (U54 Clinical Trial Optional): The objective of this Notice of Funding Opportunity (NOFO) is to invite new and renewal applications for the Rare Diseases Clinical Research Consortia (RDCRC) that comprise the Rare Diseases Clinical Research Network (RDCRN). The RDCRCs are intended to advance and improve diagnosis, management, and treatment of numerous, rare diseases through highly collaborative, multi-site, patient-centric, translational, and clinical research. Special emphasis will be placed on the early and timely identification of individuals with rare diseases and clinical trial readiness.

Federal Grant Title:	Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (RDCRN) (U54 Clinical Trial Optional)
Federal Agency Name:	National Institutes of Health (HHS-NIH11)
Grant Categories:	Health
Type of Opportunity:	Discretionary
Funding Opportunity Number:	PAR-25-438
Type of Funding:	Cooperative Agreement
CFDA Numbers:	93.121, 93.172, 93.233, 93.350, 93.837, 93.838, 93.839, 93.840, 93.846, 93.847, 93.853, 93.855, 93.865, 93.866
CFDA Descriptions:	Information not provided
Current Application Deadline:	October 16th, 2025
Original Application Deadline:	October 16th, 2025
Posted Date:	June 5th, 2025
Creation Date:	June 5th, 2025
Archive Date:	November 15th, 2025
Total Program Funding:
Maximum Federal Grant Award:	$1,000,000
Minimum Federal Grant Award:	$0
Expected Number of Awards:
Cost Sharing or Matching:	No
Last Updated:	June 5th, 2025

Applicants Eligible for this Grant: State governments - County governments - City or township governments - Independent school districts - Public and State controlled institutions of higher education - Native American tribal governments (Federally recognized) - Public housing authorities/Indian housing authorities - Native American tribal organizations (other than Federally recognized tribal governments) - Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education - Private institutions of higher education - For-profit organizations other than small businesses - Small businesses - Others (see text field entitled "Additional Information on Eligibility" for clarification.)
Additional Information on Eligibility: Higher Education Institutions - Includes all typesPublic/State Controlled Institutions of Higher EducationPrivate Institutions of Higher EducationNonprofits Other Than Institutions of Higher EducationNonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)For-Profit OrganizationsSmall BusinessesFor-Profit Organizations (Other than Small Businesses)Local GovernmentsState GovernmentsCounty GovernmentsCity or Township GovernmentsSpecial District GovernmentsIndian/Native American Tribal Governments (Federally Recognized)Indian/Native American Tribal Governments (Other than Federally Recognized)Federal GovernmentsEligible Agencies of the Federal GovernmentU.S. Territory or PossessionOtherIndependent School DistrictsPublic Housing Authorities/Indian Housing AuthoritiesNative American Tribal Organizations (other than Federally recognized tribal governments)Faith-based or Community-based OrganizationsRegional OrganizationsNon-domestic (non-U.S.) Entities (Foreign Organizations)Foreign OrganizationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Link to Full Grant Announcement: https://grants.nih.gov/grants/guide/notice-files/NOT-TR-25-008.html
Grant Announcement Contact: Tiina K. Urv, Ph.D.
[email protected]
Similar Government Grants: • Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed...; • NIDCR Dual Degree Dentist Scientist Pathway to Independence Award (K99/R00 Clinical Trial ...; • Blueprint MedTech Translator (UG3/UH3 - Clinical Trial Optional); • Short Courses on Innovative Methodologies and Approaches in the Behavioral and Social Scie...; • Leadership and Coordination Center (LACC) for the MACS/WIHS Combined Cohort Study (MWCCS) ...; • Epidemiological and Behavioral Research in Oral Health; • Metagenomic Analyses of the Oral Microbiome; • Phase Iii Clinical Trials in Oral Infectious Diseases
More Grants from the National Institutes of Health: • Single Source: National Centralized Repository for Alzheimer's Disease and Related Dementi...; • Tobacco Regulatory Science Small Grant Program for New Investigators (R03 Clinical Trial O...; • Environmental influences on Child Health Outcomes (ECHO) Cohort Data and Biospecimen Acces...; • Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed...; • Limited Competition: Regenerative Medicine Innovation Project (RMIP) Investigator-Initiate...